Enter patient *Miriam . She is in her 50s, carries some gloom and worry on her face . She has usual menopause symptoms and is managing them well ; but you see , her friend got diagnosed with stage IVB Ovarian Cancer . She didn’t have any symptoms beyond menopause symptoms ; some bloating here and there , occasional insomnia, some back pains and arthritis , on and off loss of appetite and occasional mood swings . She is worried because she wonders if her friend could have been diagnosed earlier had she seen a Gynaecologist more often . She worries if she would be to be in the same boat in the future if she doesn’t keep checking . She asks me if there is any screening test for ovarian cancer like we do for the cervix . At this time I also a remember a story told by one of my patients of a lady who died in this month of June and diagnosis of advanced ovarian cancer was only made at autopsy ; her wasting and symptoms were so vague she withered away before a diagnosis could be made .
Miriam had many other questions including if we could remove ovaries and entire reproductive system after end of childbearing age to prevent future cancers . She asks me if there are particular symptoms to be keen on. She worries if her friend’s daughters and sisters are now at risk of ovarian cancer . Keep reading , you will get answers in the write up .
It’s important to remember that there are 3 different broad categories of ovarian cancers including ovarian cancers we see much early in children up to early 20s. For this write-up I’m focusing on Epithelial type of Ovarian Cancers ; the ones that mostly inflict ladies in age 40 and above (may rarely occur earlier), are notorious for severe malignant effects and high morbidity and mortality .
There is no clear cut screening modality for ovarian cancer unless for very high risk clients with genetic predispositions or strong family histories of ovarian , breast and endometrial cancers ( and colon cancer - I won’t go here lest I bore you with advanced Gyane-oncology) . Routine tumor markers and ultrasounds/other imaging have not been seen to reduce the burden of advanced disease at diagnosis in the general population. The tumor marker for ovarian cancer called Ca-125 can be somewhat non-specific in some situations and thus not a good screening modality for the general population but only a useful tool in suspected ovarian cancer.
Some risk factors for ovarian cancer are as tabled below
Nulliparity ( having had never given birth)
Early menarche ( early age at first menses)
Late menopause
White race
Increasing age
Family history
Personal history of breast cancer
Ethnic background (European Jewish, Icelandic, Hungarian)
Postmenopausal hormone therapy
Pelvic inflammatory disease
Having more children, late beginning of menses, early menopause , is postulated to be protective against ovarian cancer . The daily combined contraceptive pill (despite its other risks) is known to be protective against ovarian cancer due to prohibition of ovulation . Uninterrupted ovulation (eg in nulliparous women) is thought to cause repetitive ovarian surface ‘damages and repairs ’ during expulsion of the monthly ‘egg’ may cause mutations and thus risk of cancer .
If you are client that has passed through my hands for permanent family planning i.e tubal ligation , you know that I’m a die-hard for total removal of the Fallopian Tube and not simply a knick and cut . I routinely do Total Salpingectomies (I remove the whole tube) because this is also known to be protective against ovarian cancer. Studies have shown that a significant number of ovarian cancers originate from lesions the finger-like ends of fallopian tubes i.e the fimbriae .
Family history of breast or ovarian cancer has been associated with Ovarian Cancer
•Approx 10% of patients have an inherited genetic predisposition with mutations in a gene called BRCA1 and BRCA2
•A family history of ovarian cancer in a 1st degree relative, that is, a mother, daughter, or sister, triples a woman's lifetime risk
•The risks further escalate with two or more an affected 1st degree relatives, or with other individuals with premenopausal breast cancer.
We have testing for the BRCA 1 and 2 gene mutations in Kenya , extremely costly but a good guide on which patients can undergo prophylactic removal of both ovaries after completion of child bearing or by age 40 years. Labs like Kalebi Lab , Lancet etc are currently doing the tests in Nairobi.
So back to Miriam’s question , can we remove the ovaries for everyone fearing ovarian cancer ? Absolutely not unless a genetic mutation is confirmed . Remember the ovaries have an estrogen producing function even in menopause albeit in reduced quantities. Estrogen is important for many other benefits in the body and protection against cardiovascular diseases and for general well being in almost all body systems including bone, skin and brain health ( story for another write up). So women undergoing surgeries say removal of uterus due to fibroids , the ovaries are mostly never touched and are left in-situ.
Symptoms : Ovarian cancer is typically portrayed as a “silent” killer that lacks appreciable early signs or symptoms. This is a misconception. Symptoms are there but vague. The difficulty is distinguishing these symptoms from those that normally occur in women especially in menopause . In general, persistent symptoms that are more severe or frequent than expected and have a recent onset warrant further diagnostic investigation. Fatigue, indigestion, inability to eat normally, constipation, and back pain may be noted . Abnormal vaginal bleeding or postmenopausal bleeding occurs rarely but if it occurs it must be investigated. May present with nausea, vomiting, and signs of intestinal obstruction. Any unexplained weight loss or a feeling of an abdominal swelling or a mass of suspicious increase in abdominal girth must be investigated.
Once you see your Gynaecologist , appropriate tests and imaging will be done and further management initiated if disease is confirmed or suspected .
For Miriam , we offered her a well detailed menopause guide talk,general examination including BP, a thorough breast , abdominal and vaginal gynaecological examination , we did cervical cancer screening via HPV testing as it was due and did an abdominal-pelvic ultrasound with focus of endometrial thickness, ovaries , and search for any abnormal findings .
A yearly Gyane-visit may be reasonable for all women and especially in menopause . Genetic testing of the gene mutations despite the high cost ( ~130,000 - 150,000 Kenya Shillings) is not unreasonable in current times to high-risk clients ( we third world countries are very quickly catching up with standard procedures done elsewhere). Maybe insurance companies can partly or fully cover this if we are ever going to reduce the incidence and burden of the monster that is ovarian cancer . These same gene mutations are also important for patients at risk for breast cancer who may need prophylactic mastectomies(removal of breasts) >> hey the breast in Kenya is considered an organ for the general surgeons and not the gyanes’; I call upon my surgeon colleagues to consider doing a blog/vlog/talk on breast cancer as well .
May you have healthy and productive ovaries all days of your life . Amen .
I tried to simplify the blog as much as possible to avoid being too academic and to minimise medical jargon . Feel free to ask any questions or to pop in for a consultation.